Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier

Valerie Cortez, David F. Boyd, Jeremy Chase Crawford, Bridgett Sharp, Brandi Livingston, Hannah M. Rowe, Amy Davis, Ramzi Alsallaq, Camenzind G. Robinson, Peter Vogel, Jason W. Rosch, Elisa Margolis, Paul G. Thomas and Stacey Schultz-Cherry ()
Additional contact information
Valerie Cortez: St. Jude Children’s Research Hospital
David F. Boyd: St. Jude Children’s Research Hospital
Jeremy Chase Crawford: St. Jude Children’s Research Hospital
Bridgett Sharp: St. Jude Children’s Research Hospital
Brandi Livingston: St. Jude Children’s Research Hospital
Hannah M. Rowe: St. Jude Children’s Research Hospital
Amy Davis: St. Jude Children’s Research Hospital
Ramzi Alsallaq: St. Jude Children’s Research Hospital
Camenzind G. Robinson: St. Jude Children’s Research Hospital
Peter Vogel: St. Jude Children’s Research Hospital
Jason W. Rosch: St. Jude Children’s Research Hospital
Elisa Margolis: St. Jude Children’s Research Hospital
Paul G. Thomas: St. Jude Children’s Research Hospital
Stacey Schultz-Cherry: St. Jude Children’s Research Hospital

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Astroviruses are a global cause of pediatric diarrhea, but they are largely understudied, and it is unclear how and where they replicate in the gut. Using an in vivo model, here we report that murine astrovirus preferentially infects actively secreting small intestinal goblet cells, specialized epithelial cells that maintain the mucus barrier. Consequently, virus infection alters mucus production, leading to an increase in mucus-associated bacteria and resistance to enteropathogenic E. coli colonization. These studies establish the main target cell type and region of the gut for productive murine astrovirus infection. They further define a mechanism by which an enteric virus can regulate the mucus barrier, induce functional changes to commensal microbial communities, and alter host susceptibility to pathogenic bacteria.

Date: 2020
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DOI: 10.1038/s41467-020-15999-y

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