Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues

Andrew R. Marderstein, Manik Uppal, Akanksha Verma, Bhavneet Bhinder, Zakieh Tayyebi, Jason Mezey, Andrew G. Clark () and Olivier Elemento ()
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Andrew R. Marderstein: Weill Cornell Medicine
Manik Uppal: Weill Cornell Medicine
Akanksha Verma: Weill Cornell Medicine
Bhavneet Bhinder: Weill Cornell Medicine
Zakieh Tayyebi: Weill Cornell Medicine
Jason Mezey: Weill Cornell Medicine
Andrew G. Clark: Weill Cornell Medicine
Olivier Elemento: Weill Cornell Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Despite infiltrating immune cells having an essential function in human disease and patients’ responses to treatments, mechanisms influencing variability in infiltration patterns remain unclear. Here, using bulk RNA-seq data from 46 tissues in the Genotype-Tissue Expression project, we apply cell-type deconvolution algorithms to evaluate the immune landscape across the healthy human body. We discover that 49 of 189 infiltration-related phenotypes are associated with either age or sex (FDR

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16097-9

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DOI: 10.1038/s41467-020-16097-9

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