Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

Fengming Liu (), Shen Dai, Dechun Feng, Zhongnan Qin, Xiao Peng, Siva S. V. P. Sakamuri, Mi Ren, Li Huang, Min Cheng, Kabir E. Mohammad, Ping Qu, Yong Chen, Chunling Zhao, Faliang Zhu, Shujian Liang, Bertal H. Aktas, Xiaofeng Yang, Hong Wang, Prasad V. G. Katakam, David W. Busija, Tracy Fischer, Prasun K. Datta, Jay Rappaport, Bin Gao and Xuebin Qin ()
Additional contact information
Fengming Liu: Tulane National Primate Research Center
Shen Dai: Temple University Lewis Katz School of Medicine
Dechun Feng: National Institutes of Health
Zhongnan Qin: Tulane National Primate Research Center
Xiao Peng: Temple University Lewis Katz School of Medicine
Siva S. V. P. Sakamuri: Tulane University School of Medicine
Mi Ren: Tulane National Primate Research Center
Li Huang: Temple University Lewis Katz School of Medicine
Min Cheng: Temple University Lewis Katz School of Medicine
Kabir E. Mohammad: Tulane National Primate Research Center
Ping Qu: Temple University Lewis Katz School of Medicine
Yong Chen: Temple University Lewis Katz School of Medicine
Chunling Zhao: Temple University Lewis Katz School of Medicine
Faliang Zhu: Temple University Lewis Katz School of Medicine
Shujian Liang: Temple University Lewis Katz School of Medicine
Bertal H. Aktas: Brigham and Women’s Hospital and Harvard Medical School
Xiaofeng Yang: Temple University Lewis Katz School of Medicine
Hong Wang: Temple University Lewis Katz School of Medicine
Prasad V. G. Katakam: Tulane University School of Medicine
David W. Busija: Tulane University School of Medicine
Tracy Fischer: Tulane National Primate Research Center
Prasun K. Datta: Temple University Lewis Katz School of Medicine
Jay Rappaport: Tulane National Primate Research Center
Bin Gao: National Institutes of Health
Xuebin Qin: Tulane National Primate Research Center

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract Renal macrophages (RMs) participate in tissue homeostasis, inflammation and repair. RMs consist of embryo-derived (EMRMs) and bone marrow-derived RMs (BMRMs), but the fate, dynamics, replenishment, functions and metabolic states of these two RM populations remain unclear. Here we investigate and characterize RMs at different ages by conditionally labeling and ablating RMs populations in several transgenic lines. We find that RMs expand and mature in parallel with renal growth after birth, and are mainly derived from fetal liver monocytes before birth, but self-maintain through adulthood with contribution from peripheral monocytes. Moreover, after the RMs niche is emptied, peripheral monocytes rapidly differentiate into BMRMs, with the CX3CR1/CX3CL1 signaling axis being essential for the maintenance and regeneration of both EMRMs and BMRMs. Lastly, we show that EMRMs have a higher capacity for scavenging immune complex, and are more sensitive to immune challenge than BMRMs, with this difference associated with their distinct glycolytic capacities.

Date: 2020
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DOI: 10.1038/s41467-020-16158-z

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