Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Wei Zhang, Tianjiao Ji, Yang Li, Yueqin Zheng, Manisha Mehta, Chao Zhao, Andong Liu and Daniel S. Kohane ()
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Wei Zhang: Harvard Medical School
Tianjiao Ji: Harvard Medical School
Yang Li: Harvard Medical School
Yueqin Zheng: Harvard Medical School
Manisha Mehta: Harvard Medical School
Chao Zhao: Harvard Medical School
Andong Liu: Harvard Medical School
Daniel S. Kohane: Harvard Medical School

Nature Communications, 2020, vol. 11, issue 1, 1-8

Abstract: Abstract An on-demand anesthetic that would only take effect when needed and where the intensity of anesthesia could be easily adjustable according to patients’ needs would be highly desirable. Here, we design and synthesize a macromolecular prodrug (P407-CM-T) in which the local anesthetic tetracaine (T) is attached to the polymer poloxamer 407 (P407) via a photo-cleavable coumarin linkage (CM). P407-CM-T solution is an injectable liquid at room temperature and gels near body temperature. The macromolecular prodrug has no anesthetic effect itself unless irradiated with a low-power blue light emitting diode (LED), resulting in local anesthesia. By adjusting the intensity and duration of irradiation, the anesthetic effect can be modulated. Local anesthesia can be repeatedly triggered.

Date: 2020
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DOI: 10.1038/s41467-020-16177-w

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