Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine

Sigrid Gouma, Madison Weirick and Scott E. Hensley ()
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Sigrid Gouma: Perelman School of Medicine, University of Pennsylvania
Madison Weirick: Perelman School of Medicine, University of Pennsylvania
Scott E. Hensley: Perelman School of Medicine, University of Pennsylvania

Nature Communications, 2020, vol. 11, issue 1, 1-5

Abstract: Abstract The 2019–2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain.

Date: 2020
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DOI: 10.1038/s41467-020-16183-y

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