Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation

Xiaoming Sun, Stephane Hua, Ce Gao, Jane E. Blackmer, Zhengyu Ouyang, Kevin Ard, Andrea Ciaranello, Sigal Yawetz, Paul E. Sax, Eric S. Rosenberg, Mathias Lichterfeld and Xu G. Yu ()
Additional contact information
Xiaoming Sun: Massachusetts General Hospital
Stephane Hua: Massachusetts General Hospital
Ce Gao: Massachusetts General Hospital
Jane E. Blackmer: Massachusetts General Hospital
Zhengyu Ouyang: Massachusetts General Hospital
Kevin Ard: Massachusetts General Hospital
Andrea Ciaranello: Massachusetts General Hospital
Sigal Yawetz: Brigham and Women’s Hospital
Paul E. Sax: Brigham and Women’s Hospital
Eric S. Rosenberg: Massachusetts General Hospital
Mathias Lichterfeld: Massachusetts General Hospital
Xu G. Yu: Massachusetts General Hospital

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Zika virus (ZIKV) is a mosquito-borne pathogen with increasing public health significance. To characterize immune responses to ZIKV, here we examine transcriptional signatures of CD4 T, CD8 T, B, and NK cells, monocytes, myeloid dendritic cells (mDCs), and plasmacytoid dendritic cells (pDCs) from three individuals with ZIKV infection. While gene expression patterns from most cell subsets display signs of impaired antiviral immune activity, pDCs from infected host have distinct transcriptional response associated with activation of innate immune recognition and type I interferon signaling pathways, but downregulation of key host factors known to support ZIKV replication steps; meanwhile, pDCs exhibit a unique expression pattern of gene modules that are correlated with alternative cell populations, suggesting collaborative interactions between pDCs and other immune cells, particularly B cells. Together, these results point towards a discrete but integrative function of pDCs in the human immune responses to ZIKV infection.

Date: 2020
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DOI: 10.1038/s41467-020-16217-5

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