Large-scale electron microscopy database for human type 1 diabetes

Pascal Boer, Nicole M. Pirozzi, Anouk H. G. Wolters, Jeroen Kuipers, Irina Kusmartseva, Mark A. Atkinson, Martha Campbell-Thompson and Ben N. G. Giepmans ()
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Pascal Boer: University of Groningen, University Medical Center Groningen
Nicole M. Pirozzi: University of Groningen, University Medical Center Groningen
Anouk H. G. Wolters: University of Groningen, University Medical Center Groningen
Jeroen Kuipers: University of Groningen, University Medical Center Groningen
Irina Kusmartseva: University of Florida Diabetes Institute
Mark A. Atkinson: University of Florida Diabetes Institute
Martha Campbell-Thompson: University of Florida Diabetes Institute
Ben N. G. Giepmans: University of Groningen, University Medical Center Groningen

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository, unprecedented in its size, composed of large-scale electron microscopy images (‘nanotomy’) of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD; www.nanotomy.org). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Anomalies we found in type 1 diabetes included (i) an increase of ‘intermediate cells’ containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate immune cells. These are our first results of mining the database and support recent findings that suggest that type 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular stress as a trigger for autoimmunity.

Date: 2020
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DOI: 10.1038/s41467-020-16287-5

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