Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

Lina Sun, Amy V. Paschall, Dustin R. Middleton, Mayumi Ishihara, Ahmet Ozdilek, Paeton L. Wantuch, Javid Aceil, Jeremy A. Duke, Celia C. LaBranche, Michael Tiemeyer and Fikri Y. Avci ()
Additional contact information
Lina Sun: University of Georgia
Amy V. Paschall: University of Georgia
Dustin R. Middleton: University of Georgia
Mayumi Ishihara: University of Georgia
Ahmet Ozdilek: University of Georgia
Paeton L. Wantuch: University of Georgia
Javid Aceil: University of Georgia
Jeremy A. Duke: University of Georgia
Celia C. LaBranche: Duke University
Michael Tiemeyer: University of Georgia
Fikri Y. Avci: University of Georgia

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract The inherent molecular complexity of human pathogens requires that mammals evolved an adaptive immune system equipped to handle presentation of non-conventional MHC ligands derived from disease-causing agents, such as HIV-1 envelope (Env) glycoprotein. Here, we report that a CD4+ T cell repertoire recognizes a glycopeptide epitope on gp120 presented by MHCII pathway. This glycopeptide is strongly immunogenic in eliciting glycan-dependent cellular and humoral immune responses. The glycopeptide specific CD4+ T cells display a prominent feature of Th2 and Th17 differentiation and exert high efficacy and potency to help Env trimer humoral immune responses. Glycopeptide-induced CD4+ T cell response prior to Env trimer immunization elicits neutralizing antibody development and production of antibodies facilitating uptake of immunogens by antigen-presenting cells. Our identification of gp120 glycopeptide–induced, T cell–specific immune responses offers a foundation for developing future knowledge-based vaccines that elicit strong and long-lasting protective immune responses against HIV-1 infection.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16319-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16319-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16319-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().