Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques

Jessica Raper, Zsofia Kovacs-Balint, Maud Mavigner, Sanjeev Gumber, Mark W. Burke, Jakob Habib, Cameron Mattingly, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M. Jean, Joyce K. Cohen, Mehul S. Suthar, Mar M. Sanchez, Maria C. Alvarado and Ann Chahroudi ()
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Jessica Raper: Emory University
Zsofia Kovacs-Balint: Emory University
Maud Mavigner: Emory University School of Medicine
Sanjeev Gumber: Emory University
Mark W. Burke: Howard University
Jakob Habib: Emory University School of Medicine
Cameron Mattingly: Emory University School of Medicine
Damien Fair: Oregon Health and Science University
Eric Earl: Oregon Health and Science University
Eric Feczko: Oregon Health and Science University
Martin Styner: University of North Carolina
Sherrie M. Jean: Emory University
Joyce K. Cohen: Emory University
Mehul S. Suthar: Emory University
Mar M. Sanchez: Emory University
Maria C. Alvarado: Emory University
Ann Chahroudi: Emory University

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Zika virus (ZIKV) infection has a profound impact on the fetal nervous system. The postnatal period is also a time of rapid brain growth, and it is important to understand the potential neurobehavioral consequences of ZIKV infection during infancy. Here we show that postnatal ZIKV infection in a rhesus macaque model resulted in long-term behavioral, motor, and cognitive changes, including increased emotional reactivity, decreased social contact, loss of balance, and deficits in visual recognition memory at one year of age. Structural and functional MRI showed that ZIKV-infected infant rhesus macaques had persistent enlargement of lateral ventricles, smaller volumes and altered functional connectivity between brain areas important for socioemotional behavior, cognitive, and motor function (e.g. amygdala, hippocampus, cerebellum). Neuropathological changes corresponded with neuroimaging results and were consistent with the behavioral and memory deficits. Overall, this study demonstrates that postnatal ZIKV infection in this model may have long-lasting neurodevelopmental consequences.

Date: 2020
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DOI: 10.1038/s41467-020-16320-7

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