Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging

Harrisson D. A. Santos, Irene Zabala Gutiérrez, Yingli Shen, José Lifante, Erving Ximendes, Marco Laurenti, Diego Méndez-González, Sonia Melle, Oscar G. Calderón, Enrique López Cabarcos, Nuria Fernández, Irene Chaves-Coira, Daniel Lucena-Agell, Luis Monge, Mark D. Mackenzie, José Marqués-Hueso, Callum M. S. Jones, Carlos Jacinto, Blanca Rosal, Ajoy K. Kar, Jorge Rubio-Retama () and Daniel Jaque ()
Additional contact information
Harrisson D. A. Santos: Universidad Autónoma de Madrid
Irene Zabala Gutiérrez: Universidad Complutense de Madrid
Yingli Shen: Universidad Autónoma de Madrid
José Lifante: Hospital Ramón y Cajal
Erving Ximendes: Universidad Autónoma de Madrid
Marco Laurenti: Universidad Complutense de Madrid
Diego Méndez-González: Universidad Complutense de Madrid
Sonia Melle: Complutense University of Madrid
Oscar G. Calderón: Complutense University of Madrid
Enrique López Cabarcos: Universidad Complutense de Madrid
Nuria Fernández: Hospital Ramón y Cajal
Irene Chaves-Coira: Universidad Autónoma de Madrid
Daniel Lucena-Agell: Consejo Superior de Investigaciones Cientificas CIB–CSIC
Luis Monge: Hospital Ramón y Cajal
Mark D. Mackenzie: Heriot-Watt University
José Marqués-Hueso: Heriot-Watt University
Callum M. S. Jones: Heriot-Watt University
Carlos Jacinto: Instituto de Física, Universidade Federal de Alagoas
Blanca Rosal: Swinburne University of Technology
Ajoy K. Kar: Heriot-Watt University
Jorge Rubio-Retama: Universidad Complutense de Madrid
Daniel Jaque: Universidad Autónoma de Madrid

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Optical probes operating in the second near-infrared window (NIR-II, 1,000-1,700 nm), where tissues are highly transparent, have expanded the applicability of fluorescence in the biomedical field. NIR-II fluorescence enables deep-tissue imaging with micrometric resolution in animal models, but is limited by the low brightness of NIR-II probes, which prevents imaging at low excitation intensities and fluorophore concentrations. Here, we present a new generation of probes (Ag2S superdots) derived from chemically synthesized Ag2S dots, on which a protective shell is grown by femtosecond laser irradiation. This shell reduces the structural defects, causing an 80-fold enhancement of the quantum yield. PEGylated Ag2S superdots enable deep-tissue in vivo imaging at low excitation intensities (

Date: 2020
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DOI: 10.1038/s41467-020-16333-2

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