FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth

Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel, Sergio Lavandero, Thomas G. Gillette and Joseph A. Hill ()
Additional contact information
Anwarul Ferdous: University of Texas Southwestern Medical Center
Zhao V. Wang: University of Texas Southwestern Medical Center
Yuxuan Luo: University of Texas Southwestern Medical Center
Dan L. Li: University of Texas Southwestern Medical Center
Xiang Luo: University of Texas Southwestern Medical Center
Gabriele G. Schiattarella: University of Texas Southwestern Medical Center
Francisco Altamirano: University of Texas Southwestern Medical Center
Herman I. May: University of Texas Southwestern Medical Center
Pavan K. Battiprolu: University of Texas Southwestern Medical Center
Annie Nguyen: University of Texas Southwestern Medical Center
Beverly A. Rothermel: University of Texas Southwestern Medical Center
Sergio Lavandero: University of Texas Southwestern Medical Center
Thomas G. Gillette: University of Texas Southwestern Medical Center
Joseph A. Hill: University of Texas Southwestern Medical Center

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and remodeling of cardiomyocytes remains unknown. Here, we report that FoxO1, but not FoxO3, activity is essential for reciprocal regulation of types II and III iodothyronine deiodinases (Dio2 and Dio3, respectively), key enzymes involved in intracellular TH metabolism. We further show that Dio2 is a direct transcriptional target of FoxO1, and the FoxO1–Dio2 axis governs TH-induced hypertrophic growth of neonatal cardiomyocytes in vitro and in vivo. Utilizing transverse aortic constriction as a model of hemodynamic stress in wild-type and cardiomyocyte-restricted FoxO1 knockout mice, we unveil an essential role for the FoxO1–Dio2 axis in afterload-induced pathological cardiac remodeling and activation of TRα1. These findings demonstrate a previously unrecognized FoxO1–Dio2 signaling axis in stress-induced cardiomyocyte growth and remodeling and intracellular TH homeostasis.

Date: 2020
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DOI: 10.1038/s41467-020-16345-y

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