Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion

Dawei Lu, Qian Luo, Rui Chen, Yongxun Zhuansun, Jie Jiang, Weichao Wang, Xuezhi Yang, Luyao Zhang, Xiaolei Liu, Fang Li, Qian Liu () and Guibin Jiang ()
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Dawei Lu: Chinese Academy of Sciences
Qian Luo: Chinese Academy of Sciences
Rui Chen: Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Yongxun Zhuansun: Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Jie Jiang: Shenzhen Center for Disease Control and Prevention
Weichao Wang: Chinese Academy of Sciences
Xuezhi Yang: Chinese Academy of Sciences
Luyao Zhang: Chinese Academy of Sciences
Xiaolei Liu: Chinese Academy of Sciences
Fang Li: Chinese Academy of Sciences
Qian Liu: Chinese Academy of Sciences
Guibin Jiang: Chinese Academy of Sciences

Nature Communications, 2020, vol. 11, issue 1, 1-8

Abstract: Abstract Ambient particulate matter pollution is one of the leading causes of global disease burden. Epidemiological studies have revealed the connections between particulate exposure and cardiovascular and respiratory diseases. However, until now, the real species of ambient ultrafine particles (UFPs) in humans are still scarcely known. Here we report the discovery and characterization of exogenous nanoparticles (NPs) in human serum and pleural effusion (PE) samples collected from non-occupational subjects in a typical polluted region. We show the wide presence of NPs in human serum and PE samples with extreme diversity in chemical species, concentration, and morphology. Through chemical multi-fingerprinting (including elemental fingerprints, high-resolution structural fingerprints, and stable iron isotopic fingerprints) of NPs, we identify the sources of the NPs to be abiogenic, particularly, combustion-derived particulate emission. Our results provide evidence for the translocation of ambient UFPs into the human circulatory system, and also provide information for understanding their systemic health effects.

Date: 2020
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DOI: 10.1038/s41467-020-16427-x

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