Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma

Sean P. Polster, Anukriti Sharma, Ceylan Tanes, Alan T. Tang, Patricia Mericko, Ying Cao, Julián Carrión-Penagos, Romuald Girard, Janne Koskimäki, Dongdong Zhang, Agnieszka Stadnik, Sharbel G. Romanos, Seán B. Lyne, Robert Shenkar, Kimberly Yan, Cornelia Lee, Amy Akers, Leslie Morrison, Myranda Robinson, Atif Zafar, Kyle Bittinger, Helen Kim, Jack A. Gilbert, Mark L. Kahn, Le Shen () and Issam A. Awad ()
Additional contact information
Sean P. Polster: The University of Chicago
Anukriti Sharma: The University of Chicago
Ceylan Tanes: Children’s Hospital of Philadelphia
Alan T. Tang: University of Pennsylvania
Patricia Mericko: University of Pennsylvania
Ying Cao: The University of Chicago
Julián Carrión-Penagos: The University of Chicago
Romuald Girard: The University of Chicago
Janne Koskimäki: The University of Chicago
Dongdong Zhang: The University of Chicago
Agnieszka Stadnik: The University of Chicago
Sharbel G. Romanos: The University of Chicago
Seán B. Lyne: The University of Chicago
Robert Shenkar: The University of Chicago
Kimberly Yan: Center for Cerebrovascular Research
Cornelia Lee: Angioma Alliance
Amy Akers: Angioma Alliance
Leslie Morrison: 1 University of New Mexico
Myranda Robinson: 1 University of New Mexico
Atif Zafar: 1 University of New Mexico
Kyle Bittinger: Children’s Hospital of Philadelphia
Helen Kim: Center for Cerebrovascular Research
Jack A. Gilbert: The University of Chicago
Mark L. Kahn: University of Pennsylvania
Le Shen: The University of Chicago
Issam A. Awad: The University of Chicago

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Cavernous angiomas (CA) are common vascular anomalies causing brain hemorrhage. Based on mouse studies, roles of gram-negative bacteria and altered intestinal homeostasis have been implicated in CA pathogenesis, and pilot study had suggested potential microbiome differences between non-CA and CA individuals based on 16S rRNA gene sequencing. We here assess microbiome differences in a larger cohort of human subjects with and without CA, and among subjects with different clinical features, and conduct more definitive microbial analyses using metagenomic shotgun sequencing. Relative abundance of distinct bacterial species in CA patients is shown, consistent with postulated permissive microbiome driving CA lesion genesis via lipopolysaccharide signaling, in humans as in mice. Other microbiome differences are related to CA clinical behavior. Weighted combinations of microbiome signatures and plasma inflammatory biomarkers enhance associations with disease severity and hemorrhage. This is the first demonstration of a sensitive and specific diagnostic microbiome in a human neurovascular disease.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16436-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16436-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16436-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().