Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

René Riedel, Richard Addo, Marta Ferreira-Gomes, Gitta Anne Heinz, Frederik Heinrich, Jannis Kummer, Victor Greiff, Daniel Schulz, Cora Klaeden, Rebecca Cornelis, Ulrike Menzel, Stefan Kröger, Ulrik Stervbo, Ralf Köhler, Claudia Haftmann, Silvia Kühnel, Katrin Lehmann, Patrick Maschmeyer, Mairi McGrath, Sandra Naundorf, Stefanie Hahne, Özen Sercan-Alp, Francesco Siracusa, Jonathan Stefanowski, Melanie Weber, Kerstin Westendorf, Jakob Zimmermann, Anja E. Hauser, Sai T. Reddy, Pawel Durek, Hyun-Dong Chang, Mir-Farzin Mashreghi () and Andreas Radbruch ()
Additional contact information
René Riedel: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Richard Addo: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Marta Ferreira-Gomes: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Gitta Anne Heinz: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Frederik Heinrich: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Jannis Kummer: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Victor Greiff: Eidgenössische Technische Hochschule (ETH Zürich)
Daniel Schulz: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Cora Klaeden: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Rebecca Cornelis: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Ulrike Menzel: Eidgenössische Technische Hochschule (ETH Zürich)
Stefan Kröger: Humboldt-Universität zu Berlin
Ulrik Stervbo: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Ralf Köhler: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Claudia Haftmann: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Silvia Kühnel: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Katrin Lehmann: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Patrick Maschmeyer: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Mairi McGrath: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Sandra Naundorf: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Stefanie Hahne: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Özen Sercan-Alp: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Francesco Siracusa: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Jonathan Stefanowski: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Melanie Weber: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Kerstin Westendorf: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Jakob Zimmermann: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Anja E. Hauser: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Sai T. Reddy: Eidgenössische Technische Hochschule (ETH Zürich)
Pawel Durek: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Hyun-Dong Chang: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Mir-Farzin Mashreghi: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association
Andreas Radbruch: Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz Association

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.

Date: 2020
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DOI: 10.1038/s41467-020-16464-6

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