Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy

Kuan Hu, Lin Xie, Yiding Zhang, Masayuki Hanyu, Zhimin Yang, Kotaro Nagatsu, Hisashi Suzuki, Jiang Ouyang, Xiaoyuan Ji, Junjie Wei, Hao Xu, Omid C. Farokhzad, Steven H. Liang (), Lu Wang (), Wei Tao () and Ming-Rong Zhang ()
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Kuan Hu: National Institutes for Quantum and Radiological Science and Technology
Lin Xie: National Institutes for Quantum and Radiological Science and Technology
Yiding Zhang: National Institutes for Quantum and Radiological Science and Technology
Masayuki Hanyu: National Institutes for Quantum and Radiological Science and Technology
Zhimin Yang: National Institutes for Quantum and Radiological Science and Technology
Kotaro Nagatsu: National Institutes for Quantum and Radiological Science and Technology
Hisashi Suzuki: National Institutes for Quantum and Radiological Science and Technology
Jiang Ouyang: Harvard Medical School
Xiaoyuan Ji: Harvard Medical School
Junjie Wei: The First Affiliated Hospital of Jinan University
Hao Xu: The First Affiliated Hospital of Jinan University
Omid C. Farokhzad: Harvard Medical School
Steven H. Liang: Harvard Medical School
Lu Wang: The First Affiliated Hospital of Jinan University
Wei Tao: Harvard Medical School
Ming-Rong Zhang: National Institutes for Quantum and Radiological Science and Technology

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract The use of photothermal agents (PTAs) in cancer photothermal therapy (PTT) has shown promising results in clinical studies. The rapid degradation of PTAs may address safety concerns but usually limits the photothermal stability required for efficacious treatment. Conversely, PTAs with high photothermal stability usually degrade slowly. The solutions that address the balance between the high photothermal stability and rapid degradation of PTAs are rare. Here, we report that the inherent Cu2+-capturing ability of black phosphorus (BP) can accelerate the degradation of BP, while also enhancing photothermal stability. The incorporation of Cu2+ into BP@Cu nanostructures further enables chemodynamic therapy (CDT)-enhanced PTT. Moreover, by employing 64Cu2+, positron emission tomography (PET) imaging can be achieved for in vivo real-time and quantitative tracking. Therefore, our study not only introduces an “ideal” PTA that bypasses the limitations of PTAs, but also provides the proof-of-concept application of BP-based materials in PET-guided, CDT-enhanced combination cancer therapy.

Date: 2020
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DOI: 10.1038/s41467-020-16513-0

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