Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers

Nathanaël Hozé, Henrik Salje, Dominique Rousset, Camille Fritzell, Jessica Vanhomwegen, Sarah Bailly, Matthieu Najm, Antoine Enfissi, Jean-Claude Manuguerra, Claude Flamand and Simon Cauchemez ()
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Nathanaël Hozé: Institut Pasteur, UMR2000, CNRS
Henrik Salje: Institut Pasteur, UMR2000, CNRS
Dominique Rousset: Institut Pasteur in French Guiana
Camille Fritzell: Institut Pasteur in French Guiana
Jessica Vanhomwegen: Institut Pasteur
Sarah Bailly: Institut Pasteur in French Guiana
Matthieu Najm: Institut Pasteur, UMR2000, CNRS
Antoine Enfissi: Institut Pasteur in French Guiana
Jean-Claude Manuguerra: Institut Pasteur
Claude Flamand: Institut Pasteur in French Guiana
Simon Cauchemez: Institut Pasteur, UMR2000, CNRS

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Characterizing the circulation of Mayaro virus (MAYV), an emerging arbovirus threat, is essential for risk assessment but challenging due to cross-reactivity with other alphaviruses such as chikungunya virus (CHIKV). Here, we develop an analytical framework to jointly assess MAYV epidemiology and the extent of cross-reactivity with CHIKV from serological data collected throughout French Guiana (N = 2697). We find strong evidence of an important sylvatic cycle for MAYV with most infections occurring near the natural reservoir in rural areas and in individuals more likely to go to the forest (i.e., adult males) and with seroprevalences of up to 18% in some areas. These findings highlight the need to strengthen MAYV surveillance in the region and showcase how modeling can improve interpretation of cross-reacting assays.

Date: 2020
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DOI: 10.1038/s41467-020-16516-x

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