A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

Jean Claude Semuto Ngabonziza, Chloé Loiseau, Michael Marceau, Agathe Jouet, Fabrizio Menardo, Oren Tzfadia, Rudy Antoine, Esdras Belamo Niyigena, Wim Mulders, Kristina Fissette, Maren Diels, Cyril Gaudin, Stéphanie Duthoy, Willy Ssengooba, Emmanuel André, Michel K. Kaswa, Yves Mucyo Habimana, Daniela Brites, Dissou Affolabi, Jean Baptiste Mazarati, Bouke Catherine de Jong, Leen Rigouts, Sebastien Gagneux (), Conor Joseph Meehan () and Philip Supply ()
Additional contact information
Jean Claude Semuto Ngabonziza: Rwanda Biomedical Center
Chloé Loiseau: Swiss Tropical and Public Health Institute
Michael Marceau: CIIL - Center for Infection and Immunity of Lille
Agathe Jouet: Genoscreen
Fabrizio Menardo: Swiss Tropical and Public Health Institute
Oren Tzfadia: Institute of Tropical Medicine
Rudy Antoine: CIIL - Center for Infection and Immunity of Lille
Esdras Belamo Niyigena: Rwanda Biomedical Center
Wim Mulders: Institute of Tropical Medicine
Kristina Fissette: Institute of Tropical Medicine
Maren Diels: Institute of Tropical Medicine
Cyril Gaudin: Genoscreen
Stéphanie Duthoy: Genoscreen
Willy Ssengooba: Makerere University
Emmanuel André: Department of Microbiology and Immunology
Michel K. Kaswa: National Tuberculosis Program
Yves Mucyo Habimana: Rwanda Biomedical Center
Daniela Brites: Swiss Tropical and Public Health Institute
Dissou Affolabi: Laboratoire de Référence des Mycobactéries
Jean Baptiste Mazarati: Rwanda Biomedical Center
Bouke Catherine de Jong: Institute of Tropical Medicine
Leen Rigouts: Institute of Tropical Medicine
Sebastien Gagneux: Swiss Tropical and Public Health Institute
Conor Joseph Meehan: Institute of Tropical Medicine
Philip Supply: CIIL - Center for Infection and Immunity of Lille

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16626-6

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DOI: 10.1038/s41467-020-16626-6

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