NAP1-RELATED PROTEIN1 and 2 negatively regulate H2A.Z abundance in chromatin in Arabidopsis

Yafei Wang, Zhenhui Zhong, Yaxin Zhang, Linhao Xu, Suhua Feng, Shima Rayatpisheh, James A. Wohlschlegel, Zonghua Wang, Steven E. Jacobsen () and Israel Ausin ()
Additional contact information
Yafei Wang: State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University
Zhenhui Zhong: University of California
Yaxin Zhang: Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University
Linhao Xu: Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben
Suhua Feng: University of California
Shima Rayatpisheh: David Geffen School of Medicine, University of California
James A. Wohlschlegel: David Geffen School of Medicine, University of California
Zonghua Wang: State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University
Steven E. Jacobsen: University of California
Israel Ausin: State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract In eukaryotes, DNA wraps around histones to form nucleosomes, which are compacted into chromatin. DNA-templated processes, including transcription, require chromatin disassembly and reassembly mediated by histone chaperones. Additionally, distinct histone variants can replace core histones to regulate chromatin structure and function. Although replacement of H2A with the evolutionarily conserved H2A.Z via the SWR1 histone chaperone complex has been extensively studied, in plants little is known about how a reduction of H2A.Z levels can be achieved. Here, we show that NRP proteins cause a decrease of H2A.Z-containing nucleosomes in Arabidopsis under standard growing conditions. nrp1-1 nrp2-2 double mutants show an over-accumulation of H2A.Z genome-wide, especially at heterochromatic regions normally H2A.Z-depleted in wild-type plants. Our work suggests that NRP proteins regulate gene expression by counteracting SWR1, thereby preventing excessive accumulation of H2A.Z.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16691-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16691-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16691-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().