The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Da Song, Deheng Wang, Qinghu Yang, Tianyi Yan, Zhe Wang, Yan Yan, Juan Zhao, Zhen Xie, Yuchen Liu, Zunji Ke, Talal Jamil Qazi, Yanhui Li, Yili Wu, Qing Shi, Yiran Lang, Heao Zhang, Tao Huang, Chunjian Wang, Zhenzhen Quan () and Hong Qing ()
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Da Song: Beijing Institute of Technology
Deheng Wang: Shanghai University of Traditional Chinese Medicine
Qinghu Yang: Beijing Institute of Technology
Tianyi Yan: Beijing Institute of Technology
Zhe Wang: Capital Medical University
Yan Yan: Beijing Institute of Technology
Juan Zhao: Beijing Institute of Technology
Zhen Xie: Beijing Institute of Technology
Yuchen Liu: Shanghai University of Traditional Chinese Medicine
Zunji Ke: Shanghai University of Traditional Chinese Medicine
Talal Jamil Qazi: Beijing Institute of Technology
Yanhui Li: Beijing Institute of Technology
Yili Wu: Jining Medical University
Qing Shi: Beijing Institute of Technology
Yiran Lang: Beijing Institute of Technology
Heao Zhang: Beijing Institute of Technology
Tao Huang: Beijing Institute of Technology
Chunjian Wang: Beijing Institute of Technology
Zhenzhen Quan: Beijing Institute of Technology
Hong Qing: Beijing Institute of Technology

Nature Communications, 2020, vol. 11, issue 1, 1-13

Abstract: Abstract The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MSPV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM.

Date: 2020
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DOI: 10.1038/s41467-020-16698-4

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