Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Lin, Yingsong; Nakatochi, Masahiro; Hosono, Yasuyuki; Ito, Hidemi; Kamatani, Yoichiro; Inoko, Akihito; Sakamoto, Hiromi; Kinoshita, Fumie; Kobayashi, Yumiko; Ishii, Hiroshi; Ozaka, Masato; Sasaki, Takashi; Matsuyama, Masato; Sasahira, Naoki; Morimoto, Manabu; Kobayashi, Satoshi; Fukushima, Taito; Ueno, Makoto; Ohkawa, Shinichi; Egawa, Naoto; Kuruma, Sawako; Mori, Mitsuru; Nakao, Haruhisa; Adachi, Yasushi; Okuda, Masumi; Osaki, Takako; Kamiya, Shigeru; Wang, Chaochen; Hara, Kazuo; Shimizu, Yasuhiro; Miyamoto, Tatsuo; Hayashi, Yuko; Ebi, Hiromichi; Kohmoto, Tomohiro; Imoto, Issei; Kasugai, Yumiko; Murakami, Yoshinori; Akiyama, Masato; Ishigaki, Kazuyoshi; Matsuda, Koichi; Hirata, Makoto; Shimada, Kazuaki; Okusaka, Takuji; Kawaguchi, Takahisa; Takahashi, Meiko; Watanabe, Yoshiyuki; Kuriki, Kiyonori; Kadota, Aya; Okada, Rieko; Mikami, Haruo; Takezaki, Toshiro; Suzuki, Sadao; Yamaji, Taiki; Iwasaki, Motoki; Sawada, Norie; Goto, Atsushi; Kinoshita, Kengo; Fuse, Nobuo; Katsuoka, Fumiki; Shimizu, Atsushi; Nishizuka, Satoshi S.; Tanno, Kozo; Suzuki, Ken; Okada, Yukinori; Horikoshi, Momoko; Yamauchi, Toshimasa; Kadowaki, Takashi; Yu, Herbert; Zhong, Jun; Amundadottir, Laufey T.; Doki, Yuichiro; Ishii, Hideshi; Eguchi, Hidetoshi; Bogumil, David; Haiman, Christopher A.; Marchand, Loic; Mori, Masaki; Risch, Harvey; Setiawan, Veronica W.; Tsugane, Shoichiro; Wakai, Kenji; Yoshida, Teruhiko; Matsuda, Fumihiko; Kubo, Michiaki; Kikuchi, Shogo; Matsuo, Keitaro

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Yingsong Lin (), Masahiro Nakatochi (), Yasuyuki Hosono, Hidemi Ito, Yoichiro Kamatani, Akihito Inoko, Hiromi Sakamoto, Fumie Kinoshita, Yumiko Kobayashi, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Masato Matsuyama, Naoki Sasahira, Manabu Morimoto, Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Shinichi Ohkawa, Naoto Egawa, Sawako Kuruma, Mitsuru Mori, Haruhisa Nakao, Yasushi Adachi, Masumi Okuda, Takako Osaki, Shigeru Kamiya, Chaochen Wang, Kazuo Hara, Yasuhiro Shimizu, Tatsuo Miyamoto, Yuko Hayashi, Hiromichi Ebi, Tomohiro Kohmoto, Issei Imoto, Yumiko Kasugai, Yoshinori Murakami, Masato Akiyama, Kazuyoshi Ishigaki, Koichi Matsuda, Makoto Hirata, Kazuaki Shimada, Takuji Okusaka, Takahisa Kawaguchi, Meiko Takahashi, Yoshiyuki Watanabe, Kiyonori Kuriki, Aya Kadota, Rieko Okada, Haruo Mikami, Toshiro Takezaki, Sadao Suzuki, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Atsushi Goto, Kengo Kinoshita, Nobuo Fuse, Fumiki Katsuoka, Atsushi Shimizu, Satoshi S. Nishizuka, Kozo Tanno, Ken Suzuki, Yukinori Okada, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki, Herbert Yu, Jun Zhong, Laufey T. Amundadottir, Yuichiro Doki, Hideshi Ishii, Hidetoshi Eguchi, David Bogumil, Christopher A. Haiman, Loic Marchand, Masaki Mori, Harvey Risch, Veronica W. Setiawan, Shoichiro Tsugane, Kenji Wakai, Teruhiko Yoshida, Fumihiko Matsuda, Michiaki Kubo, Shogo Kikuchi and Keitaro Matsuo ()
Additional contact information
Yingsong Lin: Aichi Medical University School of Medicine
Masahiro Nakatochi: Nagoya University Graduate School of Medicine
Yasuyuki Hosono: Aichi Cancer Center Research Institute
Hidemi Ito: Aichi Cancer Center Research Institute
Yoichiro Kamatani: RIKEN Center for Integrative Medical Sciences
Akihito Inoko: Aichi Cancer Center Research Institute
Hiromi Sakamoto: National Cancer Center Research Institute
Fumie Kinoshita: Nagoya University Hospital
Yumiko Kobayashi: Nagoya University Hospital
Hiroshi Ishii: Chiba Cancer Center
Masato Ozaka: The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Takashi Sasaki: The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Masato Matsuyama: The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Naoki Sasahira: The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Manabu Morimoto: Kanagawa Cancer Center
Satoshi Kobayashi: Kanagawa Cancer Center
Taito Fukushima: Kanagawa Cancer Center
Makoto Ueno: Kanagawa Cancer Center
Shinichi Ohkawa: Kanagawa Cancer Center
Naoto Egawa: Tokyo Metropolitan Hiroo Hospital
Sawako Kuruma: Tokyo Metropolitan Komagome Hospital
Mitsuru Mori: Hokkaido Chitose College of Rehabilitation
Haruhisa Nakao: Aichi Medical University School of Medicine
Yasushi Adachi: Sapporo Shirakabadai Hospital
Masumi Okuda: Hyogo College of Medicine
Takako Osaki: Kyorin University School of Medicine
Shigeru Kamiya: Kyorin University School of Medicine
Chaochen Wang: Aichi Medical University School of Medicine
Kazuo Hara: Aichi Cancer Center Hospital
Yasuhiro Shimizu: Aichi Cancer Center Hospital
Tatsuo Miyamoto: Research Institute for Radiation Biology and Medicine, Hiroshima University
Yuko Hayashi: Aichi Cancer Center Research Institute
Hiromichi Ebi: Aichi Cancer Center Research Institute
Tomohiro Kohmoto: Tokushima University Graduate School of Medicine
Issei Imoto: Aichi Cancer Center Research Institute
Yumiko Kasugai: Aichi Cancer Center Research Institute
Yoshinori Murakami: Institute of Medical Science, The University of Tokyo
Masato Akiyama: RIKEN Center for Integrative Medical Sciences
Kazuyoshi Ishigaki: RIKEN Center for Integrative Medical Sciences
Koichi Matsuda: Graduate School of Frontier Sciences, The University of Tokyo
Makoto Hirata: Institute of Medical Science, The University of Tokyo
Kazuaki Shimada: National Cancer Center Hospital
Takuji Okusaka: National Cancer Center Hospital
Takahisa Kawaguchi: Graduate School of Medicine, Kyoto University
Meiko Takahashi: Graduate School of Medicine, Kyoto University
Yoshiyuki Watanabe: Kyoto Prefectural University of Medicine
Kiyonori Kuriki: School of Food and Nutritional Sciences, University of Shizuoka
Aya Kadota: Shiga University of Medical Science
Rieko Okada: Nagoya University Graduate School of Medicine
Haruo Mikami: Chiba Cancer Center Research Institute
Toshiro Takezaki: Kagoshima University Graduate School of Medical and Dental Sciences
Sadao Suzuki: Nagoya City University Graduate School of Medical Sciences
Taiki Yamaji: National Cancer Center
Motoki Iwasaki: National Cancer Center
Norie Sawada: National Cancer Center
Atsushi Goto: National Cancer Center
Kengo Kinoshita: Tohoku University
Nobuo Fuse: Tohoku University
Fumiki Katsuoka: Tohoku University
Atsushi Shimizu: Iwate Medical University
Satoshi S. Nishizuka: Iwate Medical University
Kozo Tanno: Iwate Medical University
Ken Suzuki: RIKEN Center for Integrative Medical Sciences
Yukinori Okada: RIKEN Center for Integrative Medical Sciences
Momoko Horikoshi: RIKEN Centre for Integrative Medical Sciences
Toshimasa Yamauchi: Graduate School of Medicine, The University of Tokyo
Takashi Kadowaki: Graduate School of Medicine, The University of Tokyo
Herbert Yu: University of Hawaii Cancer Center
Jun Zhong: National Cancer Institute, National Institutes of Health
Laufey T. Amundadottir: National Cancer Institute, National Institutes of Health
Yuichiro Doki: Graduate School of Medicine, Osaka University
Hideshi Ishii: Graduate School of Medicine, Osaka University
Hidetoshi Eguchi: Graduate School of Medicine, Osaka University
David Bogumil: Keck School of Medicine, University of Southern California
Christopher A. Haiman: Keck School of Medicine, University of Southern California
Loic Marchand: University of Hawaii Cancer Center
Masaki Mori: Graduate School of Medical Sciences, Kyushu University
Harvey Risch: Yale School of Public Health
Veronica W. Setiawan: Keck School of Medicine, University of Southern California
Shoichiro Tsugane: National Cancer Center
Kenji Wakai: Nagoya University Graduate School of Medicine
Teruhiko Yoshida: National Cancer Center Research Institute
Fumihiko Matsuda: Graduate School of Medicine, Kyoto University
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
Shogo Kikuchi: Aichi Medical University School of Medicine
Keitaro Matsuo: Aichi Cancer Center Research Institute

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) genome-wide significant loci (P

Date: 2020
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DOI: 10.1038/s41467-020-16711-w

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