Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley and Kate G. R. Quinlan ()
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Alexander J. Knights: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Emily J. Vohralik: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Peter J. Houweling: The Royal Children’s Hospital
Elizabeth S. Stout: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Laura J. Norton: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Stephanie J. Alexopoulos: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Jinfen. J. Yik: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Hanapi Mat Jusoh: University of Sydney
Ellen M. Olzomer: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Kim S. Bell-Anderson: University of Sydney
Kathryn N. North: The Royal Children’s Hospital
Kyle L. Hoehn: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Merlin Crossley: School of Biotechnology and Biomolecular Sciences, UNSW Sydney
Kate G. R. Quinlan: School of Biotechnology and Biomolecular Sciences, UNSW Sydney

Nature Communications, 2020, vol. 11, issue 1, 1-12

Abstract: Abstract The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellular and molecular changes reveal an accumulation of eosinophils in adipose tissue. We examine the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging. Furthermore, we provide evidence that eosinophils may directly act on adipocytes to drive beiging and highlight the critical role of these little-understood immune cells in thermogenesis.

Date: 2020
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DOI: 10.1038/s41467-020-16758-9

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