A synthetic ion channel with anisotropic ligand response

Takahiro Muraoka (), Daiki Noguchi, Rinshi S. Kasai, Kohei Sato, Ryo Sasaki, Kazuhito V. Tabata, Toru Ekimoto, Mitsunori Ikeguchi, Kiyoto Kamagata, Norihisa Hoshino, Hiroyuki Noji, Tomoyuki Akutagawa, Kazuaki Ichimura and Kazushi Kinbara ()
Additional contact information
Takahiro Muraoka: Tokyo Institute of Technology
Daiki Noguchi: Tohoku University
Rinshi S. Kasai: Kyoto University, Shougoin
Kohei Sato: Tokyo Institute of Technology
Ryo Sasaki: Tokyo Institute of Technology
Kazuhito V. Tabata: The University of Tokyo, Bunkyo-ku
Toru Ekimoto: Yokohama City University
Mitsunori Ikeguchi: Yokohama City University
Kiyoto Kamagata: Tohoku University
Norihisa Hoshino: Tohoku University
Hiroyuki Noji: The University of Tokyo, Bunkyo-ku
Tomoyuki Akutagawa: Tohoku University
Kazuaki Ichimura: Tokyo Institute of Technology
Kazushi Kinbara: Tokyo Institute of Technology

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Biological membranes play pivotal roles in the cellular activities. Transmembrane proteins are the central molecules that conduct membrane-mediated biochemical functions such as signal transduction and substance transportation. Not only the molecular functions but also the supramolecular properties of the transmembrane proteins such as self-assembly, delocalization, orientation and signal response are essential for controlling cellular activities. Here we report anisotropic ligand responses of a synthetic multipass transmembrane ion channel. An unsymmetrical molecular structure allows for oriented insertion of the synthetic amphiphile to a bilayer by addition to a pre-formed membrane. Complexation with a ligand prompts ion transportation by forming a supramolecular channel, and removal of the ligand deactivates the transportation function. Biomimetic regulation of the synthetic channel by agonistic and antagonistic ligands is also demonstrated not only in an artificial membrane but also in a biological membrane of a living cell.

Date: 2020
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DOI: 10.1038/s41467-020-16770-z

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