Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice

Alexa N. Roth, Emily W. Helm, Carmen Mirabelli, Erin Kirsche, Jonathan C. Smith, Laura B. Eurell, Sourish Ghosh, Nihal Altan-Bonnet, Christiane E. Wobus and Stephanie M. Karst ()
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Alexa N. Roth: University of Florida
Emily W. Helm: University of Florida
Carmen Mirabelli: University of Michigan
Erin Kirsche: University of Florida
Jonathan C. Smith: University of Florida
Laura B. Eurell: University of Florida
Sourish Ghosh: Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health
Nihal Altan-Bonnet: Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health
Christiane E. Wobus: University of Michigan
Stephanie M. Karst: University of Florida

Nature Communications, 2020, vol. 11, issue 1, 1-8

Abstract: Abstract Human noroviruses are the leading cause of severe childhood diarrhea worldwide, yet we know little about their pathogenic mechanisms. Murine noroviruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence in the translatability of findings to human norovirus disease. Herein we report that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirroring the key features of human norovirus disease and representing a norovirus small animal disease model in wild-type mice. Intriguingly, lymphocytes are critical for controlling acute norovirus replication while simultaneously contributing to disease severity, likely reflecting their dual role as targets of viral infection and key components of the host response.

Date: 2020
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DOI: 10.1038/s41467-020-16798-1

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