Using arterial–venous analysis to characterize cancer metabolic consumption in patients

Nanxiang Xiong (), Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G. Zacharias, Hong Lin, Hieu S. Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J. DeBerardinis, Hao Xu and Woo-ping Ge ()
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Nanxiang Xiong: Huazhong University of Science and Technology
Xiaofei Gao: University of Texas Southwestern Medical Center
Hongyang Zhao: Huazhong University of Science and Technology
Feng Cai: University of Texas Southwestern Medical Center
Fang-cheng Zhang: Huazhong University of Science and Technology
Ye Yuan: Huazhong University of Science and Technology
Weichao Liu: Huazhong University of Science and Technology
Fangping He: Zhejiang University
Lauren G. Zacharias: University of Texas Southwestern Medical Center
Hong Lin: Huazhong University of Science and Technology
Hieu S. Vu: University of Texas Southwestern Medical Center
Chao Xing: University of Texas Southwestern Medical Center
Dong-Xiao Yao: Huazhong University of Science and Technology
Fei Chen: University of Texas Southwestern Medical Center
Benyan Luo: University of Texas Southwestern Medical Center
Wenzhi Sun: Chinese Institute for Brain Research, Beijing
Ralph J. DeBerardinis: University of Texas Southwestern Medical Center
Hao Xu: Huazhong University of Science and Technology
Woo-ping Ge: Chinese Institute for Brain Research, Beijing

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Understanding tumor metabolism holds the promise of new insights into cancer biology, diagnosis and treatment. To assess human cancer metabolism, here we report a method to collect intra-operative samples of blood from an artery directly upstream and a vein directly downstream of a brain tumor, as well as samples from dorsal pedal veins of the same patients. After performing targeted metabolomic analysis, we characterize the metabolites consumed and produced by gliomas in vivo by comparing the arterial supply and venous drainage. N-acetylornithine, D-glucose, putrescine, and L-acetylcarnitine are consumed in relatively large amounts by gliomas. Conversely, L-glutamine, agmatine, and uridine 5-monophosphate are produced in relatively large amounts by gliomas. Further we verify that D-2-hydroxyglutarate (D-2HG) is high in venous plasma from patients with isocitrate dehydrogenases1 (IDH1) mutations. Through these paired comparisons, we can exclude the interpatient variation that is present in plasma samples usually taken from the cubital vein.

Date: 2020
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DOI: 10.1038/s41467-020-16810-8

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