An Erg-driven transcriptional program controls B cell lymphopoiesis

Ashley P. Ng (), Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt and Warren S. Alexander
Additional contact information
Ashley P. Ng: The Walter and Eliza Hall Institute of Medical Research
Hannah D. Coughlan: The University of Melbourne
Soroor Hediyeh-zadeh: The Walter and Eliza Hall Institute of Medical Research
Kira Behrens: The Walter and Eliza Hall Institute of Medical Research
Timothy M. Johanson: The University of Melbourne
Michael Sze Yuan Low: The University of Melbourne
Charles C. Bell: Peter MacCallum Cancer Centre
Omer Gilan: Peter MacCallum Cancer Centre
Yih-Chih Chan: Peter MacCallum Cancer Centre
Andrew J. Kueh: The Walter and Eliza Hall Institute of Medical Research
Thomas Boudier: The University of Melbourne
Rebecca Feltham: The Walter and Eliza Hall Institute of Medical Research
Anna Gabrielyan: The Walter and Eliza Hall Institute of Medical Research
Ladina DiRago: The Walter and Eliza Hall Institute of Medical Research
Craig D. Hyland: The Walter and Eliza Hall Institute of Medical Research
Helen Ierino: The Walter and Eliza Hall Institute of Medical Research
Sandra Mifsud: The Walter and Eliza Hall Institute of Medical Research
Elizabeth Viney: The Walter and Eliza Hall Institute of Medical Research
Tracy Willson: The Walter and Eliza Hall Institute of Medical Research
Mark A. Dawson: Peter MacCallum Cancer Centre
Rhys S. Allan: The University of Melbourne
Marco J. Herold: The Walter and Eliza Hall Institute of Medical Research
Kelly Rogers: The University of Melbourne
David M. Tarlinton: Monash University
Gordon K. Smyth: The University of Melbourne
Melissa J. Davis: The University of Melbourne
Stephen L. Nutt: The University of Melbourne
Warren S. Alexander: The Walter and Eliza Hall Institute of Medical Research

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature B cells. This highly regulated process generates clonal immunological diversity via recombination of immunoglobulin V, D and J gene segments. While several transcription factors that control B cell development and V(D)J recombination have been defined, how these processes are initiated and coordinated into a precise regulatory network remains poorly understood. Here, we show that the transcription factor ETS Related Gene (Erg) is essential for early B lymphoid differentiation. Erg initiates a transcriptional network involving the B cell lineage defining genes, Ebf1 and Pax5, which directly promotes expression of key genes involved in V(D)J recombination and formation of the B cell receptor. Complementation of Erg deficiency with a productively rearranged immunoglobulin gene rescued B lineage development, demonstrating that Erg is an essential and stage-specific regulator of the gene regulatory network controlling B lymphopoiesis.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16828-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16828-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16828-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().