Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage

Jinman Chen, Linmei Wang, Hao Xu, Lianping Xing, Zixin Zhuang, Yangkang Zheng, Xuefei Li, Chinyun Wang, Shaohua Chen, Zibin Guo, Qianqian Liang () and Yongjun Wang ()
Additional contact information
Jinman Chen: Shanghai University of Traditional Chinese Medicine
Linmei Wang: Shanghai University of Traditional Chinese Medicine
Hao Xu: Shanghai University of Traditional Chinese Medicine
Lianping Xing: University of Rochester Medical Center
Zixin Zhuang: Shanghai University of Traditional Chinese Medicine
Yangkang Zheng: Shanghai University of Traditional Chinese Medicine
Xuefei Li: Shanghai University of Traditional Chinese Medicine
Chinyun Wang: Shanghai University of Traditional Chinese Medicine
Shaohua Chen: Shanghai University of Traditional Chinese Medicine
Zibin Guo: Guangzhou University of Traditional Chinese Medicine
Qianqian Liang: Shanghai University of Traditional Chinese Medicine
Yongjun Wang: Shanghai University of Traditional Chinese Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been reported to drain macromolecules and immune cells from CSF into cervical lymph nodes (CLNs). However, whether meningeal lymphatics are involved in clearing extravasated erythrocytes in CSF after SAH remains unclear. Here we show that a markedly higher number of erythrocytes are accumulated in the lymphatics of CLNs and meningeal lymphatics after SAH. When the meningeal lymphatics are depleted in a mouse model of SAH, the degree of erythrocyte aggregation in CLNs is significantly lower, while the associated neuroinflammation and the neurologic deficits are dramatically exacerbated. In addition, during SAH lymph flow is increased but without significant lymphangiogenesis and lymphangiectasia. Taken together, this work demonstrates that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH, while suggesting that modulating this draining may offer therapeutic approaches to alleviate SAH severity.

Date: 2020
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16851-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16851-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16851-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().