Diauxie and co-utilization of carbon sources can coexist during bacterial growth in nutritionally complex environments

Elena Perrin, Veronica Ghini, Michele Giovannini, Francesca Di Patti, Barbara Cardazzo, Lisa Carraro, Camilla Fagorzi, Paola Turano, Renato Fani and Marco Fondi ()
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Elena Perrin: University of Florence
Veronica Ghini: Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP)
Michele Giovannini: University of Florence
Francesca Di Patti: University of Florence
Barbara Cardazzo: University of Padova
Lisa Carraro: University of Padova
Camilla Fagorzi: University of Florence
Paola Turano: Center of Magnetic Resonance (CERM), University of Florence
Renato Fani: University of Florence
Marco Fondi: University of Florence

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract It is commonly thought that when multiple carbon sources are available, bacteria metabolize them either sequentially (diauxic growth) or simultaneously (co-utilization). However, this view is mainly based on analyses in relatively simple laboratory settings. Here we show that a heterotrophic marine bacterium, Pseudoalteromonas haloplanktis, can use both strategies simultaneously when multiple possible nutrients are provided in the same growth experiment. The order of nutrient uptake is partially determined by the biomass yield that can be achieved when the same compounds are provided as single carbon sources. Using transcriptomics and time-resolved intracellular 1H-13C NMR, we reveal specific pathways for utilization of various amino acids. Finally, theoretical modelling indicates that this metabolic phenotype, combining diauxie and co-utilization of substrates, is compatible with a tight regulation that allows the modulation of assimilatory pathways.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16872-8

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DOI: 10.1038/s41467-020-16872-8

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