Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Eva Hadadi (), William Taylor, Xiao-Mei Li, Yetki Aslan, Marthe Villote, Julie Rivière, Gaelle Duvallet, Charlotte Auriau, Sandrine Dulong, Isabelle Raymond-Letron, Sylvain Provot, Annelise Bennaceur-Griscelli and Hervé Acloque ()
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Eva Hadadi: Université Paris Sud
William Taylor: Université Paris Sud
Xiao-Mei Li: Université Paris Sud
Yetki Aslan: Université Paris Diderot, Hôpital Lariboisière - Centre Viggo Petersen
Marthe Villote: Université Paris-Saclay
Julie Rivière: Université Paris-Saclay
Gaelle Duvallet: Inserm
Charlotte Auriau: Inserm
Sandrine Dulong: Université Paris Sud
Isabelle Raymond-Letron: Université de Toulouse
Sylvain Provot: Université Paris Diderot, Hôpital Lariboisière - Centre Viggo Petersen
Annelise Bennaceur-Griscelli: Université Paris Sud
Hervé Acloque: Université Paris Sud

Nature Communications, 2020, vol. 11, issue 1, 1-17

Abstract: Abstract Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16890-6

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DOI: 10.1038/s41467-020-16890-6

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