EEG microstates are a candidate endophenotype for schizophrenia

Janir Ramos da Cruz (), Ophélie Favrod, Maya Roinishvili, Eka Chkonia, Andreas Brand, Christine Mohr, Patrícia Figueiredo and Michael H. Herzog
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Janir Ramos da Cruz: École Polytechnique Fédérale de Lausanne (EPFL)
Ophélie Favrod: École Polytechnique Fédérale de Lausanne (EPFL)
Maya Roinishvili: Beritashvili Centre of Experimental Biomedicine
Eka Chkonia: Free University of Tbilisi
Andreas Brand: École Polytechnique Fédérale de Lausanne (EPFL)
Christine Mohr: Institut de Psychologie, Bâtiment Geopolis
Patrícia Figueiredo: Universidade de Lisboa
Michael H. Herzog: École Polytechnique Fédérale de Lausanne (EPFL)

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Electroencephalogram microstates are recurrent scalp potential configurations that remain stable for around 90 ms. The dynamics of two of the four canonical classes of microstates, commonly labeled as C and D, have been suggested as a potential endophenotype for schizophrenia. For endophenotypes, unaffected relatives of patients must show abnormalities compared to controls. Here, we examined microstate dynamics in resting-state recordings of unaffected siblings of patients with schizophrenia, patients with schizophrenia, healthy controls, and patients with first episodes of psychosis (FEP). Patients with schizophrenia and their siblings showed increased presence of microstate class C and decreased presence of microstate class D compared to controls. No difference was found between FEP and chronic patients. Our findings suggest that the dynamics of microstate classes C and D are a candidate endophenotype for schizophrenia.

Date: 2020
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DOI: 10.1038/s41467-020-16914-1

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