Iron imaging in myocardial infarction reperfusion injury

Brianna F. Moon, Srikant Kamesh Iyer, Eileen Hwuang, Michael P. Solomon, Anya T. Hall, Rishabh Kumar, Nicholas J. Josselyn, Elizabeth M. Higbee-Dempsey, Andrew Tsourkas, Akito Imai, Keitaro Okamoto, Yoshiaki Saito, James J. Pilla, Joseph H. Gorman, Robert C. Gorman, Cory Tschabrunn, Samuel J. Keeney, Estibaliz Castillero, Giovanni Ferrari, Steffen Jockusch, Felix W. Wehrli, Haochang Shou, Victor A. Ferrari, Yuchi Han, Avanti Gulhane, Harold Litt, William Matthai and Walter R. Witschey ()
Additional contact information
Brianna F. Moon: University of Pennsylvania
Srikant Kamesh Iyer: University of Pennsylvania
Eileen Hwuang: University of Pennsylvania
Michael P. Solomon: University of Pennsylvania
Anya T. Hall: University of Pennsylvania
Rishabh Kumar: University of Pennsylvania
Nicholas J. Josselyn: University of Pennsylvania
Elizabeth M. Higbee-Dempsey: University of Pennsylvania
Andrew Tsourkas: University of Pennsylvania
Akito Imai: University of Pennsylvania
Keitaro Okamoto: University of Pennsylvania
Yoshiaki Saito: University of Pennsylvania
James J. Pilla: University of Pennsylvania
Joseph H. Gorman: University of Pennsylvania
Robert C. Gorman: University of Pennsylvania
Cory Tschabrunn: University of Pennsylvania
Samuel J. Keeney: University of Pennsylvania
Estibaliz Castillero: Columbia University Irving Medical Center
Giovanni Ferrari: Columbia University Irving Medical Center
Steffen Jockusch: Columbia University
Felix W. Wehrli: University of Pennsylvania
Haochang Shou: University of Pennsylvania
Victor A. Ferrari: University of Pennsylvania
Yuchi Han: University of Pennsylvania
Avanti Gulhane: University of Pennsylvania
Harold Litt: University of Pennsylvania
William Matthai: University of Pennsylvania
Walter R. Witschey: University of Pennsylvania

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we report that magnetic susceptibility imaging in a large animal model shows an infarct paramagnetic shift associated with duration of coronary artery occlusion and the presence of iron. Iron validation techniques used include histology, immunohistochemistry, spectrometry and spectroscopy. Further mRNA analysis shows upregulation of ferritin and heme oxygenase. While conventional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has improved sensitivity to iron and mitigates confounding factors such as edema and fibrosis. Myocardial infarction patients receiving reperfusion therapy show magnetic susceptibility changes associated with hypokinetic myocardial wall motion and microvascular obstruction, demonstrating potential for clinical translation.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-16923-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16923-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-16923-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().