Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity

Gui-Yuan Wu, Xueliang Shi (), Hoa Phan, Hang Qu, Yi-Xiong Hu, Guang-Qiang Yin, Xiao-Li Zhao, Xiaopeng Li, Lin Xu, Qilin Yu () and Hai-Bo Yang ()
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Gui-Yuan Wu: East China Normal University
Xueliang Shi: East China Normal University
Hoa Phan: Vinh University
Hang Qu: Xiamen University
Yi-Xiong Hu: East China Normal University
Guang-Qiang Yin: East China Normal University
Xiao-Li Zhao: East China Normal University
Xiaopeng Li: University of South Florida
Lin Xu: East China Normal University
Qilin Yu: Nankai University
Hai-Bo Yang: East China Normal University

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. We herein report a highly efficient self-assembly of heterometallic triangular necklace 1 containing Cu and Pt metals with strong antibacterial activity. Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing motif. The superior antibacterial activity of necklace 1 against both standard and clinically drug-resistant pathogens implies that the presence of Cu(I) center and platinum(II) significantly enhance the bacterium-binding/damaging activity, which is mainly attributed to the highly positively charged nature, the possible synergistic effect of heterometals in the necklace, and the improved stability in culture media. This work clearly discloses the structure-property relationships that the existence of two different metal centers not only facilitates successful construction of heterometallic triangular necklace but also endows it with superior nuclease properties and antibacterial activities.

Date: 2020
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DOI: 10.1038/s41467-020-16940-z

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