Alterations of gut microbiota contribute to the progression of unruptured intracranial aneurysms

Hao Li, Haochen Xu, Youxiang Li, Yuhua Jiang, Yamin Hu, Tingting Liu, Xueqing Tian, Xihai Zhao, Yandong Zhu, Shuxia Wang, Chunrui Zhang, Jing Ge, Xuliang Wang, Hongyan Wen, Congxia Bai, Yingying Sun, Li Song, Yinhui Zhang, Rutai Hui, Jun Cai and Jingzhou Chen ()
Additional contact information
Hao Li: Chinese Academy of Medical Sciences and Peking Union Medical College
Haochen Xu: Chinese Academy of Medical Sciences and Peking Union Medical College
Youxiang Li: Capital Medical University
Yuhua Jiang: Capital Medical University
Yamin Hu: Cangzhou Central Hospital
Tingting Liu: Chinese Academy of Medical Sciences and Peking Union Medical College
Xueqing Tian: Chinese Academy of Medical Sciences and Peking Union Medical College
Xihai Zhao: Tsinghua University
Yandong Zhu: Tsinghua University
Shuxia Wang: Chinese PLA General Hospital and Chinese PLA Medical College
Chunrui Zhang: Novogene Bioinformatics Institute
Jing Ge: Chinese Academy of Medical Sciences and Peking Union Medical College
Xuliang Wang: Chinese Academy of Medical Sciences and Peking Union Medical College
Hongyan Wen: Chinese Academy of Medical Sciences and Peking Union Medical College
Congxia Bai: Chinese Academy of Medical Sciences and Peking Union Medical College
Yingying Sun: Chinese Academy of Medical Sciences and Peking Union Medical College
Li Song: Chinese Academy of Medical Sciences and Peking Union Medical College
Yinhui Zhang: Chinese Academy of Medical Sciences and Peking Union Medical College
Rutai Hui: Chinese Academy of Medical Sciences and Peking Union Medical College
Jun Cai: Chinese Academy of Medical Sciences and Peking Union Medical College
Jingzhou Chen: Chinese Academy of Medical Sciences and Peking Union Medical College

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Unruptured intracranial aneurysm (UIA) is a life-threatening cerebrovascular condition. Whether changes in gut microbial composition participate in the development of UIAs remains largely unknown. We perform a case-control metagenome-wide association study in two cohorts of Chinese UIA patients and control individuals and mice that receive fecal transplants from human donors. After fecal transplantation, the UIA microbiota is sufficient to induce UIAs in mice. We identify UIA-associated gut microbial species link to changes in circulating taurine. Specifically, the abundance of Hungatella hathewayi is markedly decreased and positively correlated with the circulating taurine concentration in both humans and mice. Consistently, gavage with H. hathewayi normalizes the taurine levels in serum and protects mice against the formation and rupture of intracranial aneurysms. Taurine supplementation also reverses the progression of intracranial aneurysms. Our findings provide insights into a potential role of H. hathewayi-associated taurine depletion as a key factor in the pathogenesis of UIAs.

Date: 2020
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DOI: 10.1038/s41467-020-16990-3

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