A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

Yanjun Guo (), Pamela M. Rist, Iyas Daghlas, Franco Giulianini, Tobias Kurth and Daniel I. Chasman ()
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Yanjun Guo: Division of Preventive Medicine, Brigham and Women’s Hospital
Pamela M. Rist: Division of Preventive Medicine, Brigham and Women’s Hospital
Iyas Daghlas: Division of Preventive Medicine, Brigham and Women’s Hospital
Franco Giulianini: Division of Preventive Medicine, Brigham and Women’s Hospital
Tobias Kurth: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Daniel I. Chasman: Division of Preventive Medicine, Brigham and Women’s Hospital

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P

Date: 2020
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DOI: 10.1038/s41467-020-17002-0

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