Single-atom Ni-N4 provides a robust cellular NO sensor

Min Zhou, Ying Jiang, Guo Wang, Wenjie Wu, Wenxing Chen, Ping Yu, Yuqing Lin (), Junjie Mao () and Lanqun Mao ()
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Min Zhou: Capital Normal University
Ying Jiang: Beijing Normal University
Guo Wang: Capital Normal University
Wenjie Wu: the Chinese Academy of Sciences (CAS)
Wenxing Chen: Beijing Institute of Technology
Ping Yu: the Chinese Academy of Sciences (CAS)
Yuqing Lin: Capital Normal University
Junjie Mao: Anhui Normal University
Lanqun Mao: the Chinese Academy of Sciences (CAS)

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Nitric oxide (NO) has been implicated in a variety of physiological and pathological processes. Monitoring cellular levels of NO requires a sensor to feature adequate sensitivity, transient recording ability and biocompatibility. Herein we report a single-atom catalysts (SACs)-based electrochemical sensor for the detection of NO in live cellular environment. The system employs nickel single atoms anchored on N-doped hollow carbon spheres (Ni SACs/N-C) that act as an excellent catalyst for electrochemical oxidation of NO. Notably, Ni SACs/N-C shows superior electrocatalytic performance to the commonly used Ni based nanomaterials, attributing from the greatly reduced Gibbs free energy that are required for Ni SACs/N-C in activating NO oxidation. Moreover, Ni SACs-based flexible and stretchable sensor shows high biocompatibility and low nanomolar sensitivity, enabling the real-time monitoring of NO release from cells upon drug and stretch stimulation. Our results demonstrate a promising means of using SACs for electrochemical sensing applications.

Date: 2020
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DOI: 10.1038/s41467-020-17018-6

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