An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment

Corine H. GeurtsvanKessel (), Nisreen M. A. Okba, Zsofia Igloi, Susanne Bogers, Carmen W. E. Embregts, Brigitta M. Laksono, Lonneke Leijten, Casper Rokx, Bart Rijnders, Janette Rahamat-Langendoen, Johannes P. C. van den Akker, Jeroen J. A. van Kampen, Annemiek A. van der Eijk, Rob S. van Binnendijk, Bart Haagmans and Marion Koopmans
Additional contact information
Corine H. GeurtsvanKessel: Erasmus MC
Nisreen M. A. Okba: Erasmus MC
Zsofia Igloi: Erasmus MC
Susanne Bogers: Erasmus MC
Carmen W. E. Embregts: Erasmus MC
Brigitta M. Laksono: Erasmus MC
Lonneke Leijten: Erasmus MC
Casper Rokx: Section of Infectious Diseaseas, Erasmus MC
Bart Rijnders: Section of Infectious Diseaseas, Erasmus MC
Janette Rahamat-Langendoen: Radboud University Medical Centre
Johannes P. C. van den Akker: Erasmus MC
Jeroen J. A. van Kampen: Erasmus MC
Annemiek A. van der Eijk: Erasmus MC
Rob S. van Binnendijk: Center for Infectious Disease Control, RIVM
Bart Haagmans: Erasmus MC
Marion Koopmans: Erasmus MC

Nature Communications, 2020, vol. 11, issue 1, 1-5

Abstract: Abstract The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the selected assays there is a wide diversity in assay performance in different scenarios and when correlated to virus neutralizing antibodies. The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. The large variety of available serological assays requires proper assay validation before deciding on deployment of assays for specific applications.

Date: 2020
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DOI: 10.1038/s41467-020-17317-y

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