Zika virus vertical transmission in children with confirmed antenatal exposure

Patrícia Brasil (), Zilton Vasconcelos, Tara Kerin, Claudia Raja Gabaglia, Ieda P. Ribeiro, Myrna C. Bonaldo, Luana Damasceno, Marcos V. Pone, Sheila Pone, Andrea Zin, Irena Tsui, Kristina Adachi, Jose Paulo Pereira, Stephanie L. Gaw, Liege Carvalho, Denise C. Cunha, Leticia Guida, Mirza Rocha, James D. Cherry, Lulan Wang, Saba Aliyari, Genhong Cheng, Suan-Sin Foo, Weiqiang Chen, Jae Jung, Elizabeth Brickley, Maria Elisabeth L. Moreira and Karin Nielsen-Saines ()
Additional contact information
Patrícia Brasil: Fundação Oswaldo Cruz
Zilton Vasconcelos: Fundação Oswaldo Cruz
Tara Kerin: David Geffen UCLA School of Medicine
Claudia Raja Gabaglia: Biomedical Research Institute of Southern California
Ieda P. Ribeiro: Fundação Oswaldo Cruz
Myrna C. Bonaldo: Fundação Oswaldo Cruz
Luana Damasceno: Fundação Oswaldo Cruz
Marcos V. Pone: Fundação Oswaldo Cruz
Sheila Pone: Fundação Oswaldo Cruz
Andrea Zin: Fundação Oswaldo Cruz
Irena Tsui: David Geffen UCLA School of Medicine
Kristina Adachi: David Geffen UCLA School of Medicine
Jose Paulo Pereira: Fundação Oswaldo Cruz
Stephanie L. Gaw: University of California, San Francisco School of Medicine
Liege Carvalho: Fundação Oswaldo Cruz
Denise C. Cunha: Fundação Oswaldo Cruz
Leticia Guida: Fundação Oswaldo Cruz
Mirza Rocha: Fundação Oswaldo Cruz
James D. Cherry: David Geffen UCLA School of Medicine
Lulan Wang: David Geffen UCLA School of Medicine
Saba Aliyari: David Geffen UCLA School of Medicine
Genhong Cheng: David Geffen UCLA School of Medicine
Suan-Sin Foo: University of Southern California
Weiqiang Chen: University of Southern California
Jae Jung: University of Southern California
Elizabeth Brickley: London School of Hygiene and Tropical Medicine
Maria Elisabeth L. Moreira: Fundação Oswaldo Cruz
Karin Nielsen-Saines: David Geffen UCLA School of Medicine

Nature Communications, 2020, vol. 11, issue 1, 1-8

Abstract: Abstract We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of the Rio de Janeiro epidemic of 2015–2016. Serum and urine collected from birth through the first year of life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM Zika MAC-ELISA. Four hundred and seven specimens are evaluated; 161 sera tested by PCR and IgM assays, 85 urines by PCR. Sixty-five percent of children (N = 84) are positive in at least one assay. Of 94 children tested within 3 months of age, 70% are positive. Positivity declines to 33% after 3 months. Five children are PCR+ beyond 200 days of life. Concordance between IgM and PCR results is 52%, sensitivity 65%, specificity 40% (positive PCR results as gold standard). IgM and serum PCR are 61% concordant; serum and urine PCR 55%. Most children (65%) are clinically normal. Equal numbers of children with abnormal findings (29 of 45, 64%) and normal findings (55 of 85, 65%) have positive results, p = 0.98. Earlier maternal trimester of infection is associated with positive results (p = 0.04) but not clinical disease (p = 0.98). ZIKV vertical transmission is frequent but laboratory confirmed infection is not necessarily associated with infant abnormalities.

Date: 2020
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DOI: 10.1038/s41467-020-17331-0

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