Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo

Gabriela Arias-Alpizar, Li Kong, Redmar C. Vlieg, Alexander Rabe, Panagiota Papadopoulou, Michael S. Meijer, Sylvestre Bonnet, Stefan Vogel, John Noort, Alexander Kros () and Frederick Campbell ()
Additional contact information
Gabriela Arias-Alpizar: Leiden Institute of Chemistry (LIC), Leiden University
Li Kong: Leiden Institute of Chemistry (LIC), Leiden University
Redmar C. Vlieg: Leiden Institute of Physics (LION), Leiden University
Alexander Rabe: University of Southern Denmark
Panagiota Papadopoulou: Leiden Institute of Chemistry (LIC), Leiden University
Michael S. Meijer: Leiden Institute of Chemistry (LIC), Leiden University
Sylvestre Bonnet: Leiden Institute of Chemistry (LIC), Leiden University
Stefan Vogel: University of Southern Denmark
John Noort: Leiden Institute of Physics (LION), Leiden University
Alexander Kros: Leiden Institute of Chemistry (LIC), Leiden University
Frederick Campbell: Leiden Institute of Chemistry (LIC), Leiden University

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Surface charge plays a fundamental role in determining the fate of a nanoparticle, and any encapsulated contents, in vivo. Herein, we describe, and visualise in real time, light-triggered switching of liposome surface charge, from neutral to cationic, in situ and in vivo (embryonic zebrafish). Prior to light activation, intravenously administered liposomes, composed of just two lipid reagents, freely circulate and successfully evade innate immune cells present in the fish. Upon in situ irradiation and surface charge switching, however, liposomes rapidly adsorb to, and are taken up by, endothelial cells and/or are phagocytosed by blood resident macrophages. Coupling complete external control of nanoparticle targeting together with the intracellular delivery of encapsulated (and membrane impermeable) cargos, these compositionally simple liposomes are proof that advanced nanoparticle function in vivo does not require increased design complexity but rather a thorough understanding of the fundamental nano-bio interactions involved.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-17360-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17360-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-17360-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().