TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing

Theresa Schöpp, Ansgar Zoch, Rebecca V. Berrens, Tania Auchynnikava, Yuka Kabayama, Lina Vasiliauskaitė, Juri Rappsilber, Robin C. Allshire and Dónal O’Carroll ()
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Theresa Schöpp: University of Edinburgh
Ansgar Zoch: University of Edinburgh
Rebecca V. Berrens: University of Cambridge, Li Ka Shing Centre, Robinson Way
Tania Auchynnikava: University of Edinburgh
Yuka Kabayama: University of Edinburgh
Lina Vasiliauskaitė: University of Edinburgh
Juri Rappsilber: University of Edinburgh
Robin C. Allshire: University of Edinburgh
Dónal O’Carroll: University of Edinburgh

Nature Communications, 2020, vol. 11, issue 1, 1-8

Abstract: Abstract The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. piRNAs are proposed to recruit MIWI2 to the transcriptionally active TE loci by base pairing to nascent transcripts, however the downstream mechanisms and effector proteins utilized by MIWI2 in directing de novo TE methylation remain incompletely understood. Here, we show that MIWI2 associates with TEX15 in foetal gonocytes. TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing. In summary, TEX15 is an essential executor of mammalian piRNA-directed DNA methylation.

Date: 2020
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DOI: 10.1038/s41467-020-17372-5

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