Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction

Jacqueline Saw (), Min-Lee Yang, Mark Trinder, Catherine Tcheandjieu, Chang Xu, Andrew Starovoytov, Isabelle Birt, Michael R. Mathis, Kristina L. Hunker, Ellen M. Schmidt, Linda Jackson, Natalia Fendrikova-Mahlay, Matthew Zawistowski, Chad M. Brummett, Sebastian Zoellner, Alexander Katz, Dawn M. Coleman, Kirby Swan, Christopher J. O’Donnell, Xiang Zhou, Jun Z. Li, Heather L. Gornik, Themistocles L. Assimes, James C. Stanley, Liam R. Brunham and Santhi K. Ganesh ()
Additional contact information
Jacqueline Saw: University of British Columbia
Min-Lee Yang: University of Michigan Medical School
Mark Trinder: University of British Columbia
Catherine Tcheandjieu: VA Palo Alto Health Care System
Chang Xu: University of Michigan School of Public Health
Andrew Starovoytov: University of British Columbia
Isabelle Birt: University of Michigan Medical School
Michael R. Mathis: University of Michigan
Kristina L. Hunker: University of Michigan Medical School
Ellen M. Schmidt: University of Michigan School of Public Health
Linda Jackson: University of British Columbia
Natalia Fendrikova-Mahlay: Heart and Vascular Institute, Cleveland Clinic
Matthew Zawistowski: University of Michigan School of Public Health
Chad M. Brummett: University of Michigan
Sebastian Zoellner: University of Michigan School of Public Health
Alexander Katz: University of Michigan Medical School
Dawn M. Coleman: University of Michigan
Kirby Swan: University of Michigan Medical School
Christopher J. O’Donnell: VA Boston Healthcare System
Xiang Zhou: University of Michigan School of Public Health
Jun Z. Li: University of Michigan Medical School
Heather L. Gornik: Heart and Vascular Institute, Cleveland Clinic
Themistocles L. Assimes: VA Palo Alto Health Care System
James C. Stanley: University of Michigan
Liam R. Brunham: University of British Columbia
Santhi K. Ganesh: University of Michigan Medical School

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (Ncases = 270/Ncontrols = 5,263) and identified and replicated an association of rs12740679 at chromosome 1q21.2 (Pdiscovery+replication = 2.19 × 10−12, OR = 1.8) influencing ADAMTSL4 expression. Meta-analysis of discovery and replication samples identified associations with P

Date: 2020
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DOI: 10.1038/s41467-020-17558-x

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