Homogeneous and heterogeneous catalytic reduction of amides and related compounds using molecular hydrogen

Jose R. Cabrero-Antonino, Rosa Adam (), Veronica Papa and Matthias Beller ()
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Jose R. Cabrero-Antonino: Instituto de Tecnología Química. Universitat Politècnica de València - Consejo Superior Investigaciones Científicas (UPV-CSIC). Avda. de los Naranjos s/n
Rosa Adam: Instituto de Tecnología Química. Universitat Politècnica de València - Consejo Superior Investigaciones Científicas (UPV-CSIC). Avda. de los Naranjos s/n
Veronica Papa: Leibniz-Institut für Katalyse
Matthias Beller: Leibniz-Institut für Katalyse

Nature Communications, 2020, vol. 11, issue 1, 1-18

Abstract: Abstract Catalytic hydrogenation of amides is of great interest for chemists working in organic synthesis, as the resulting amines are widely featured in natural products, drugs, agrochemicals, dyes, etc. Compared to traditional reduction of amides using (over)stoichiometric reductants, the direct hydrogenation of amides using molecular hydrogen represents a greener approach. Furthermore, amide hydrogenation is a highly versatile transformation, since not only higher amines (obtained by C–O cleavage), but also lower amines and alcohols, or amino alcohols (obtained by C–N cleavage) can be selectively accessed by fine tuning of reaction conditions. This review describes the most recent advances in the area of amide hydrogenation using H2 exclusively and molecularly defined homogeneous as well as nano-structured heterogeneous catalysts, with a special focus on catalyst development and synthetic applications.

Date: 2020
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DOI: 10.1038/s41467-020-17588-5

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