Auxin-induced signaling protein nanoclustering contributes to cell polarity formation

Xue Pan, Linjing Fang, Jianfeng Liu, Betul Senay-Aras, Wenwei Lin, Shuan Zheng, Tong Zhang, Jingzhe Guo, Uri Manor, Jaimie Norman, Weitao Chen () and Zhenbiao Yang ()
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Xue Pan: Fujian Agriculture and Forestry University
Linjing Fang: Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies
Jianfeng Liu: University of California
Betul Senay-Aras: University of California
Wenwei Lin: Fujian Agriculture and Forestry University
Shuan Zheng: Fujian Agriculture and Forestry University
Tong Zhang: Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies
Jingzhe Guo: University of California
Uri Manor: Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies
Jaimie Norman: University of California
Weitao Chen: University of California
Zhenbiao Yang: University of California

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract Cell polarity is fundamental to the development of both eukaryotes and prokaryotes, yet the mechanisms behind its formation are not well understood. Here we found that, phytohormone auxin-induced, sterol-dependent nanoclustering of cell surface transmembrane receptor kinase 1 (TMK1) is critical for the formation of polarized domains at the plasma membrane (PM) during the morphogenesis of cotyledon pavement cells (PC) in Arabidopsis. Auxin-induced TMK1 nanoclustering stabilizes flotillin1-associated ordered nanodomains, which in turn promote the nanoclustering of ROP6 GTPase that acts downstream of TMK1 to regulate cortical microtubule organization. In turn, cortical microtubules further stabilize TMK1- and flotillin1-containing nanoclusters at the PM. Hence, we propose a new paradigm for polarity formation: A diffusive signal triggers cell polarization by promoting cell surface receptor-mediated nanoclustering of signaling components and cytoskeleton-mediated positive feedback that reinforces these nanodomains into polarized domains.

Date: 2020
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DOI: 10.1038/s41467-020-17602-w

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