European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Weang-Kee Ho (), Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo () and Antonis C. Antoniou
Additional contact information
Weang-Kee Ho: University of Nottingham Malaysia
Min-Min Tan: University of Nottingham Malaysia
Nasim Mavaddat: University of Cambridge
Mei-Chee Tai: Cancer Research Malaysia
Shivaani Mariapun: University of Nottingham Malaysia
Jingmei Li: Human Genetics, Genome Institute of Singapore
Peh-Joo Ho: Human Genetics, Genome Institute of Singapore
Joe Dennis: University of Cambridge
Jonathan P. Tyrer: University of Cambridge
Manjeet K. Bolla: University of Cambridge
Kyriaki Michailidou: University of Cambridge
Qin Wang: University of Cambridge
Daehee Kang: Seoul National University College of Medicine
Ji-Yeob Choi: Seoul National University Graduate School
Suniza Jamaris: University of Malaya, Jalan Universiti
Xiao-Ou Shu: Vanderbilt University School of Medicine
Sook-Yee Yoon: Cancer Research Malaysia
Sue K. Park: Seoul National University College of Medicine
Sung-Won Kim: Daerim Saint Mary’s Hospital
Chen-Yang Shen: Institute of Biomedical Sciences, Academia Sinica
Jyh-Cherng Yu: Tri-Service General Hospital
Ern Yu Tan: Tan Tock Seng Hospital
Patrick Mun Yew Chan: Tan Tock Seng Hospital
Kenneth Muir: The University of Manchester
Artitaya Lophatananon: The University of Manchester
Anna H. Wu: University of Southern California
Daniel O. Stram: University of Southern California
Keitaro Matsuo: Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
Hidemi Ito: Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
Ching Wan Chan: National University of Singapore
Joanne Ngeow: Division of Medical Oncology, National Cancer Centre Singapore
Wei Sean Yong: Division of Surgical Oncology, National Cancer Centre
Swee Ho Lim: KK Women’s and Children’s Hospital
Geok Hoon Lim: KK Women’s and Children’s Hospital
Ava Kwong: Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre
Tsun L. Chan: Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre
Su Ming Tan: General Surgery, Changi General Hospital
Jaime Seah: General Surgery, Changi General Hospital
Esther M. John: Stanford University School of Medicine
Allison W. Kurian: Stanford University School of Medicine
Woon-Puay Koh: Health Services and Systems Research, Duke-NUS Medical School, Stanford University School of Medicine
Chiea Chuen Khor: Human Genetics, Genome Institute of Singapore
Motoki Iwasaki: Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
Taiki Yamaji: Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
Kiak Mien Veronique Tan: Division of Surgical Oncology, National Cancer Centre
Kiat Tee Benita Tan: Division of Surgical Oncology, National Cancer Centre
John J. Spinelli: Population Oncology, BC Cancer, 675 West 10th Avenue
Kristan J. Aronson: Queen’s University
Siti Norhidayu Hasan: Cancer Research Malaysia
Kartini Rahmat: University of Malaya
Anushya Vijayananthan: University of Malaya
Xueling Sim: Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
Paul D. P. Pharoah: University of Cambridge
Wei Zheng: Vanderbilt University School of Medicine
Alison M. Dunning: University of Cambridge
Jacques Simard: CHU de Québec-Université Laval Research 2705 Blvd Laurier Québec (Québec) G1V 4G2
Rob Martinus Dam: Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
Cheng-Har Yip: Sime Darby Medical Centre
Nur Aishah Mohd Taib: University of Malaya, Jalan Universiti
Mikael Hartman: National University Hospital and NUHS
Douglas F. Easton: University of Cambridge
Soo-Hwang Teo: Cancer Research Malaysia
Antonis C. Antoniou: University of Cambridge

Nature Communications, 2020, vol. 11, issue 1, 1-11

Abstract: Abstract Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

Date: 2020
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DOI: 10.1038/s41467-020-17680-w

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