A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy

Giovanni J. Ughi, Miklos G. Marosfoi, Robert M. King, Jildaz Caroff, Lindsy M. Peterson, Benjamin H. Duncan, Erin T. Langan, Amanda Collins, Anita Leporati, Serge Rousselle, Demetrius K. Lopes, Matthew J. Gounis () and Ajit S. Puri
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Giovanni J. Ughi: University of Massachusetts Medical School
Miklos G. Marosfoi: University of Massachusetts Medical School
Robert M. King: University of Massachusetts Medical School
Jildaz Caroff: University of Massachusetts Medical School
Lindsy M. Peterson: Gentuity LLC
Benjamin H. Duncan: Gentuity LLC
Erin T. Langan: University of Massachusetts Medical School
Amanda Collins: University of Massachusetts Medical School
Anita Leporati: University of Massachusetts Medical School
Serge Rousselle: Alizée Pathology, Inc
Demetrius K. Lopes: Advocate Health
Matthew J. Gounis: University of Massachusetts Medical School
Ajit S. Puri: University of Massachusetts Medical School

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract Intravascular imaging has emerged as a valuable tool for the treatment of coronary and peripheral artery disease; however, no solution is available for safe and reliable use in the tortuous vascular anatomy of the brain. Endovascular treatment of stroke is delivered under image guidance with insufficient resolution to adequately assess underlying arterial pathology and therapeutic devices. High-resolution imaging, enabling surgeons to visualize cerebral arteries' microstructure and micron-level features of neurovascular devices, would have a profound impact in the research, diagnosis, and treatment of cerebrovascular diseases. Here, we present a neurovascular high-frequency optical coherence tomography (HF-OCT) system, including an imaging console and an endoscopic probe designed to rapidly acquire volumetric microscopy data at a resolution approaching 10 microns in tortuous cerebrovascular anatomies. Using a combination of in vitro, ex vivo, and in vivo models, the feasibility of HF-OCT for cerebrovascular imaging was demonstrated.

Date: 2020
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DOI: 10.1038/s41467-020-17702-7

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