Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice

Elisa M. Nabel, Yury Garkun, Hiroyuki Koike, Masato Sadahiro, Ana Liang, Kevin J. Norman, Giulia Taccheri, Michael P. Demars, Susanna Im, Keaven Caro, Sarah Lopez, Julia Bateh, Patrick R. Hof, Roger L. Clem and Hirofumi Morishita ()
Additional contact information
Elisa M. Nabel: Icahn School of Medicine at Mount Sinai
Yury Garkun: Icahn School of Medicine at Mount Sinai
Hiroyuki Koike: Icahn School of Medicine at Mount Sinai
Masato Sadahiro: Icahn School of Medicine at Mount Sinai
Ana Liang: Icahn School of Medicine at Mount Sinai
Kevin J. Norman: Icahn School of Medicine at Mount Sinai
Giulia Taccheri: Icahn School of Medicine at Mount Sinai
Michael P. Demars: Icahn School of Medicine at Mount Sinai
Susanna Im: Icahn School of Medicine at Mount Sinai
Keaven Caro: Icahn School of Medicine at Mount Sinai
Sarah Lopez: Icahn School of Medicine at Mount Sinai
Julia Bateh: Icahn School of Medicine at Mount Sinai
Patrick R. Hof: Icahn School of Medicine at Mount Sinai
Roger L. Clem: Icahn School of Medicine at Mount Sinai
Hirofumi Morishita: Icahn School of Medicine at Mount Sinai

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract Frontal top-down cortical neurons projecting to sensory cortical regions are well-positioned to integrate long-range inputs with local circuitry in frontal cortex to implement top-down attentional control of sensory regions. How adolescence contributes to the maturation of top-down neurons and associated local/long-range input balance, and the establishment of attentional control is poorly understood. Here we combine projection-specific electrophysiological and rabies-mediated input mapping in mice to uncover adolescence as a developmental stage when frontal top-down neurons projecting from the anterior cingulate to visual cortex are highly functionally integrated into local excitatory circuitry and have heightened activity compared to adulthood. Chemogenetic suppression of top-down neuron activity selectively during adolescence, but not later periods, produces long-lasting visual attentional behavior deficits, and results in excessive loss of local excitatory inputs in adulthood. Our study reveals an adolescent sensitive period when top-down neurons integrate local circuits with long-range connectivity to produce attentional behavior.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-17787-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17787-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-17787-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().