A spike-timing-dependent plasticity rule for dendritic spines

Sabrina Tazerart, Diana E. Mitchell, Soledad Miranda-Rottmann and Roberto Araya ()
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Sabrina Tazerart: University of Montreal
Diana E. Mitchell: University of Montreal
Soledad Miranda-Rottmann: University of Montreal
Roberto Araya: University of Montreal

Nature Communications, 2020, vol. 11, issue 1, 1-16

Abstract: Abstract The structural organization of excitatory inputs supporting spike-timing-dependent plasticity (STDP) remains unknown. We performed a spine STDP protocol using two-photon (2P) glutamate uncaging (pre) paired with postsynaptic spikes (post) in layer 5 pyramidal neurons from juvenile mice. Here we report that pre-post pairings that trigger timing-dependent LTP (t-LTP) produce shrinkage of the activated spine neck and increase in synaptic strength; and post-pre pairings that trigger timing-dependent LTD (t-LTD) decrease synaptic strength without affecting spine shape. Furthermore, the induction of t-LTP with 2P glutamate uncaging in clustered spines ( 40 μm. These results indicate that synaptic cooperativity disrupts t-LTD and extends the temporal window for the induction of t-LTP, leading to STDP only encompassing LTP.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17861-7

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DOI: 10.1038/s41467-020-17861-7

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