Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

Louis Faure, Yiqiao Wang, Maria Eleni Kastriti, Paula Fontanet, Kylie K. Y. Cheung, Charles Petitpré, Haohao Wu, Lynn Linyu Sun, Karen Runge, Laura Croci, Mark A. Landy, Helen C. Lai, Gian Giacomo Consalez, Antoine Chevigny, François Lallemend, Igor Adameyko and Saida Hadjab ()
Additional contact information
Louis Faure: Medical University Vienna
Yiqiao Wang: Karolinska Institutet
Maria Eleni Kastriti: Medical University Vienna
Paula Fontanet: Karolinska Institutet
Kylie K. Y. Cheung: Karolinska Institutet
Charles Petitpré: Karolinska Institutet
Haohao Wu: Karolinska Institutet
Lynn Linyu Sun: Karolinska Institutet
Karen Runge: Aix-Marseille University
Laura Croci: Università Vita-Salute San Raffaele
Mark A. Landy: UT Southwestern Medical Center
Helen C. Lai: UT Southwestern Medical Center
Gian Giacomo Consalez: Università Vita-Salute San Raffaele
Antoine Chevigny: Aix-Marseille University
François Lallemend: Karolinska Institutet
Igor Adameyko: Medical University Vienna
Saida Hadjab: Karolinska Institutet

Nature Communications, 2020, vol. 11, issue 1, 1-15

Abstract: Abstract Somatic sensation is defined by the existence of a diversity of primary sensory neurons with unique biological features and response profiles to external and internal stimuli. However, there is no coherent picture about how this diversity of cell states is transcriptionally generated. Here, we use deep single cell analysis to resolve fate splits and molecular biasing processes during sensory neurogenesis in mice. Our results identify a complex series of successive and specific transcriptional changes in post-mitotic neurons that delineate hierarchical regulatory states leading to the generation of the main sensory neuron classes. In addition, our analysis identifies previously undetected early gene modules expressed long before fate determination although being clearly associated with defined sensory subtypes. Overall, the early diversity of sensory neurons is generated through successive bi-potential intermediates in which synchronization of relevant gene modules and concurrent repression of competing fate programs precede cell fate stabilization and final commitment.

Date: 2020
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DOI: 10.1038/s41467-020-17929-4

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