Dscam1 establishes the columnar units through lineage-dependent repulsion between sister neurons in the fly brain

Chuyan Liu, Olena Trush, Xujun Han, Miaoxing Wang, Rie Takayama, Tetsuo Yasugi, Takashi Hayashi and Makoto Sato ()
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Chuyan Liu: Kanazawa University
Olena Trush: Kanazawa University
Xujun Han: Kanazawa University
Miaoxing Wang: Kanazawa University
Rie Takayama: Kanazawa University
Tetsuo Yasugi: Kanazawa University
Takashi Hayashi: Kanazawa University
Makoto Sato: Kanazawa University

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract The brain is organized morphologically and functionally into a columnar structure. According to the radial unit hypothesis, neurons from the same lineage form a radial unit that contributes to column formation. However, the molecular mechanisms that link neuronal lineage and column formation remain elusive. Here, we show that neurons from the same lineage project to different columns under control of Down syndrome cell adhesion molecule (Dscam) in the fly brain. Dscam1 is temporally expressed in newly born neuroblasts and is inherited by their daughter neurons. The transient transcription of Dscam1 in neuroblasts enables the expression of the same Dscam1 splice isoform within cells of the same lineage, causing lineage-dependent repulsion. In the absence of Dscam1 function, neurons from the same lineage project to the same column. When the splice diversity of Dscam1 is reduced, column formation is significantly compromised. Thus, Dscam1 controls column formation through lineage-dependent repulsion.

Date: 2020
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DOI: 10.1038/s41467-020-17931-w

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