Preventing and treating PTSD-like memory by trauma contextualization

Alice Shaam Al Abed, Eva-Gunnel Ducourneau, Chloé Bouarab, Azza Sellami, Aline Marighetto and Aline Desmedt ()
Additional contact information
Alice Shaam Al Abed: Physiopathologie de la plasticité neuronale, U1215, INSERM
Eva-Gunnel Ducourneau: Physiopathologie de la plasticité neuronale, U1215, INSERM
Chloé Bouarab: Physiopathologie de la plasticité neuronale, U1215, INSERM
Azza Sellami: Physiopathologie de la plasticité neuronale, U1215, INSERM
Aline Marighetto: Physiopathologie de la plasticité neuronale, U1215, INSERM
Aline Desmedt: Physiopathologie de la plasticité neuronale, U1215, INSERM

Nature Communications, 2020, vol. 11, issue 1, 1-9

Abstract: Abstract Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on trauma contextualization and the underlying hippocampal mechanisms.

Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-020-18002-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18002-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-020-18002-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().