Steps towards standardized quantification of adult neurogenesis

Xinyu Zhao () and Henriette van Praag ()
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Xinyu Zhao: Waisman Center and University of Wisconsin-Madison
Henriette van Praag: Brain Institute and Charles E. Schmidt College of Medicine, Florida Atlantic University

Nature Communications, 2020, vol. 11, issue 1, 1-10

Abstract: Abstract New neurons are generated in adult mammals. Adult hippocampal neurogenesis is considered to play an important role in cognition and mental health. The number and properties of newly born neurons are regulatable by a broad range of physiological and pathological conditions. To begin to understand the underlying cellular mechanisms and functional relevance of adult neurogenesis, many studies rely on quantification of adult-born neurons. However, lack of standardized methods to quantify new neurons is impeding research reproducibility across laboratories. Here, we review the importance of stereology, and propose why and how it should be applied to the study of adult neurogenesis.

Date: 2020
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DOI: 10.1038/s41467-020-18046-y

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