Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

Peishan Li, Ming Lu, Jiayuan Shi, Li Hua, Zheng Gong, Qing Li, Leonard D. Shultz and Guangwen Ren ()
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Peishan Li: Shandong University
Ming Lu: The Jackson Laboratory
Jiayuan Shi: The Jackson Laboratory
Li Hua: The Jackson Laboratory
Zheng Gong: The Jackson Laboratory
Qing Li: The Jackson Laboratory
Leonard D. Shultz: The Jackson Laboratory
Guangwen Ren: The Jackson Laboratory

Nature Communications, 2020, vol. 11, issue 1, 1-14

Abstract: Abstract The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have been reported. In this study, using mouse models of breast cancer, we demonstrate that the metastasis-modulating effects of neutrophils are dictated by the status of host natural killer (NK) cells. In NK cell-deficient mice, granulocyte colony-stimulating factor-expanded neutrophils show an inhibitory effect on the metastatic colonization of breast tumor cells in the lung. In contrast, in NK cell-competent mice, neutrophils facilitate metastatic colonization in the same tumor models. In an ex vivo neutrophil-NK cell-tumor cell tri-cell co-culture system, neutrophils are shown to potentially suppress the tumoricidal activity of NK cells, while neutrophils themselves are tumoricidal. Intriguingly, these two modulatory effects by neutrophils are both mediated by reactive oxygen species. Collectively, the absence or presence of NK cells, governs the net tumor-modulatory effects of neutrophils.

Date: 2020
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DOI: 10.1038/s41467-020-18125-0

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